How to permanently disable wake-on-mouse in Windows 10?

I have always had the same issue with all of my Windows 10 computers - it is essentially impossible to put the computer to sleep with the mouse. When I click Start > Power > Sleep, the computer goes to sleep instantly. Then the act of lifting my hand from the mouse moves the mouse enough to immediately wake the computer from sleep.

Usually, I'm able to fix this issue by disabling "Allow this device to wake the computer" in Device Manager (until the device manager decides that I'm using a new mouse due to system updates or using a different USB port).

However, on my Asus laptop, it seems impossible to actually stop the mouse from waking the laptop:

• I have disabled "Allow this device to wake the computer" for all devices that have this option in the Device Manager.
• powercfg lastwake shows "Wake History Count - 0."
• powercfg -devicequery wake_armed shows "NONE."
• There are no options related to power management/wake-from-sleep in the ASUS UEFI.

I can put the computer to sleep via the keyboard or by folding the lid as a workaround, but inevitably at some point the mouse will randomly decide that it's moved at least 1/600th of an inch and the computer will wake up. The only real solution I've found is to unplug the mouse before putting the computer to sleep, which is rather inconvenient.

Are there any additional steps that I can take to prevent the mouse from ever waking the computer? I am looking for a solution that does not require any third-party software.

OK, I signed up for an account because this was driving me crazy, too. This didn't solve my problem, but it at least answered the question, and may help solve it for someone else.

I came across this very well written post on Windows 11 Forum that explains the issue:

Your computer is behaving correctly. There is no "fix" for what you are experiencing because there is no fault. You do not have "sleep" despite MS muddying the waters by leaving that as the name of the action in Start, Power & using the word elsewhere. There is no need to run any diagnostic test of any kind. There is no fix of any kind. You have S0 Modern standby aka S0 Low power idle. It is an idle condition. It is not "sleep".

Basically, the traditional "sleep" state (aka "S3", "Standby", or "Suspend to RAM"), where everything was shut off, but RAM kept power so the machine could quickly be woken up has been replaced by a new mode also called "Sleep" (aka "S0 Sleep" or "Modern Standby") where basically the computer stays on and just allows fewer programs to run. This is a result of Microsoft's desire to have computers come to life instantly like people are used to powering on smart phones.

Unfortunately it seems like the Device Manager settings for allowing a device to wake only apply to the older "S3" Sleep, and coming to life with mouse movement is just part and parcel of the new "Modern standby", unfortunately. :(

It seems like (unfortunately for me) on the newest generation of systems there is no support for S3 sleep, but it seems like on some of the systems just a couple years older there is a way to force S3 sleep instead of S0 sleep. You can Google around for how to disable "Modern standby" on your particular computer/O.S. combo. Good luck!